Burundanga: The Drug Against Free Will

It turns out that ‘free will’ is a brain process that can be shut off. Wired UK explores the plant-derived drug — currently all the rage in the South American criminal underworld — that does this:

Burundanga is a scary drug. According to news reports from Ecuador, the last thing a motorist could recall, after waking up minus his car and possessions, was being approached by two women; in Venezuela, a girl came round in hospital to find she had been abducted and sexually assaulted. Each had been doped with burundanga, an extract of the brugmansia plant containing high levels of the psychoactive chemical scopolamine.
News reports allude to a sinister effect: that the drug removes free will, effectively turning victims into suggestible human puppets. Although not fully understood by neuroscience, free will is seen as a highly complex neurological ability and one of the most cherished of human characteristics. Clearly, if a drug can eliminate this, it highlights a stark vulnerability at the core of our species.
It is known that scopolamine affects memory and makes people more passive. Neuroscientist Renate Thienel notes that “scopolamine has a selective effect on memory, although other mental functions, such as planning and information manipulation, are unaffected.” This suggests victims remain cognitively nimble but unable to retain information.
The key seems to be that scopolamine blocks acetylcholine, a neurotransmitter essential to memory. Scans also reveal the drug affects the amygdala, a brain area controlling aggression and anxiety. Evidence suggests victims tend to be confused and passive rather than unable to resist commands. Yet, until scopolamine’s role in the chemistry of free will is fully explored, we can only speculate that the criminal underworld has unwittingly stumbled upon one of the greatest discoveries of 21st-century neuroscience.